1597005

Quinine sulfate

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : Quinine hemisulfate salt monohydrate, Quinine sulfate (2:1) (salt) dihydrate
• Formule empirique (notation de Hill): C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O
• Numéro CAS: 207671-44-1
• Poids moléculaire : 391.47
• Numéro Beilstein : 6113937
• Numéro MDL: MFCD00150790
• Code UNSPSC : 41116107
• ID de substance PubChem : 329751013
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: quinine
• Poids mol.: monograph mol wt. 782.94
• Fabricant/nom de marque: USP
• Pf: ~225 °C (dec.) (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
• Clé InChI: ZHNFLHYOFXQIOW-LPYZJUEESA-N

Description

Description générale

(C₂₀H₂₄N₂O₂)₂ . H₂SO₄ . 2H₂O

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Quinine sulfate is the sulfate salt of quinine, an alkaloid, obtained from the bark of Cinchona species.

Application

Quinine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Quinine Sulfate Capsules
• Quinine Sulfate Tablets

Actions biochimiques/physiologiques

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable