T6031

DL-Thiorphan

≥98% (TLC)

• Synonyme(s) : (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine
• Formule empirique (notation de Hill): C₁₂H₁₅NO₃S
• Numéro CAS: 76721-89-6
• Poids moléculaire : 253.32
• Beilstein: 4872101
• Numéro MDL: MFCD00058435
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278747
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Pf: 138 °C
• Solubilité: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• Chaîne SMILES: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
• Clé InChI: LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• Informations sur le gène: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

Description

Description générale

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

Application

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Actions biochimiques/physiologiques

Enkephalinase inhibitor.

Caractéristiques et avantages

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)