T103

Trifluperidol hydrochloride

• Synonyme(s) : 4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m tolyl)piperidino]butyrophenone hydrochloride, R 2498, Triperidol
• Formule empirique (notation de Hill) : C₂₂H₂₃F₄NO₂ · HCl
• Numéro CAS: 2062-77-3
• Poids moléculaire : 445.88
• NACRES: NA.77
• PubChem Substance ID: 24277941
• UNSPSC Code: 12352200
• EC Number: 218-170-1
• MDL number: MFCD00055195
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL, H₂O: soluble, ethanol: moderately soluble
• SMILES string: Cl.OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3cccc(c3)C(F)(F)F
• InChI: 1S/C22H23F4NO2.ClH/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26;/h1,3-4,6-9,15,29H,2,5,10-14H2;1H
• InChI key: VYGQXRZAHIZHQV-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Application

The interaction of Trifluperidol hydrochloride with NMDA receptors was studied in rat brain buffy coat membranes.

Biochem/physiol Actions

Trifluperidol is a dopamine receptor antagonist with antipsychotic effects used in the treatment of schizophrenia. This neuroleptic penetrates the brain and also affects the glial cells leading to increased release of proinflammatory cytokines. It also alters the metabolism of carbohydrates and amino acids in the brain cortex.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mot-clé: Danger
• Codes de danger: H301
• Mentions de précaution: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges