SML2527

SW063058

≥98% (HPLC)

• Synonyme(s) : 7-Bromo-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-4-(2-iodobenzoyl)-2H-1,4-benzodiazepin-2-one
• Formule empirique (notation de Hill): C₂₂H₁₅BrFIN₂O₂
• Numéro CAS: 533876-30-1
• Poids moléculaire : 565.17
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: Ic1c(cccc1)C(=O)N2C(c4c(ccc(c4)Br)NC(=O)C2)c3ccc(cc3)F
• InChI: 1S/C22H15BrFIN2O2/c23-14-7-10-19-17(11-14)21(13-5-8-15(24)9-6-13)27(12-20(28)26-19)22(29)16-3-1-2-4-18(16)25/h1-11,21H,12H2,(H,26,28)
• Clé InChI: CFXZDEOFOAXVPQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

SW063058 is an autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding, versus Bax/Bcl-2 binding. SW063058 acts by disrupting the binding of Bcl-2, a negative regulator of autophagy, to the BH3 domain of Beclin 1, which is involved in autophagy initiation. It does not inhibit Bcl-2 binding to the BH3 domain of the pro-apoptotic Bcl-2 family members BAX and BIM. In vitro experiments showed that SW063058 was not cytotoxic and induced autophagy without inducing apoptosis or other forms of cell death.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable