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Purmorphamine

≥98% (HPLC), powder, Hedgehog signaling activator

Synonyme(s) :

2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-

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A propos de cet article

Formule empirique (notation de Hill) :
C31H32N6O2
Numéro CAS:
Poids moléculaire :
520.62
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Nom du produit

Purmorphamine, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4

InChI

1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

InChI key

FYBHCRQFSFYWPY-UHFFFAOYSA-N

Application

Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish.

Biochem/physiol Actions

Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor.
Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor. In various studies, purmorphamine has been shown to induce osteoblast differentiation, generate cardiomyocytes from human embryonic stem cells, increase the neuronal differentiation of a human striatal neural stem cell line, and to differentiate human umbilical cord mesenchymal stem cells (hUCMSCs) into motoneurons.

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Cet article
540220540223Z744976
description

≥98% (HPLC)

description

A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM).

description

InSolution, ≥98%, 50 mM in DMSO, induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells

description

temp. range 0—200 °F, diam. 3 in., stem L 48 in. ×

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

solid

form

liquid

form

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 200 mg/mL

solubility

-

solubility

-

color

white to beige

color

off-white

color

-

color

-


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Pictogrammes

Health hazard

Mot-clé

Warning

Codes de danger

Hazard Classifications

Muta. 2

Classe de stockage

11 - Combustible Solids

Que se passe-t-il ?

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable



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Questions

  1. What is the stability of purmorphamine as solid and in solution of DMSO ?

    1 answer
    1. This product is not assigned an expiration date or retest schedule. Products that are robust and extremely stable in their original unopened container are not assigned an expiration date or retest schedule. These products will not have dating reported on either the label or the Certificate of Analysis. Products without an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment. Full product dating information can be reviewed at the following link: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdf. Stability in solution has not been internally validated. Other sources recommend storing at -20°C and using it within 1 year. It is advised to aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

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