SML0443

SU-5402

≥98% (HPLC), powder, FGFR inhibitor

• Synonyme(s) : 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid, PF-02969207, PNU-0290908
• Formule empirique (notation de Hill): C₁₇H₁₆N₂O₃
• Numéro CAS: 215543-92-3
• Poids moléculaire : 296.32
• Numéro MDL: MFCD08235144
• Code UNSPSC : 51111800
• ID de substance PubChem : 329824725
• Nomenclature NACRES : NA.77

Propriétés

• product name: SU-5402, ≥98% (HPLC)
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: light yellow to dark orange
• Solubilité: DMSO: 10 mg/mL (clear solution)
• Température de stockage: −20°C
• Chaîne SMILES: Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
• InChI: 1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
• Clé InChI: JNDVEAXZWJIOKB-JYRVWZFOSA-N

Description

Application

SU5402 has been used as a fibroblast growth factor receptor inhibitor:

• in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
• to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
• to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
• to study its effect on osteogenic markers.

Actions biochimiques/physiologiques

SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).

SU-5402 is a FGFR antagonist and angiogenesis inhibitor.

Caractéristiques et avantages

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Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable