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Key Documents

SMB00292

Sigma-Aldrich

Fengycin

≥90%

Synonyme(s) :

Fengycin, Plipastatin

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About This Item

Formule empirique (notation de Hill):
C72H110N12O20
Poids moléculaire :
1463.71
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.85

Source biologique

Bacillus subtilis

Pureté

≥90%

Forme

powder

Couleur

, Off-White to Light Yellow to Light Brown

Spectre d'activité de l'antibiotique

fungi

Mode d’action

cell membrane | interferes

Température de stockage

2-8°C

Description générale

Chemical structure: peptide
Fengycin is a lipopeptide complex which is synthesized by Bacillus subtilis strain F-29-3. It is an antifungal compound, and is made up of two components namely, fengycin A and fengycin B. Fengycin A contains 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-Glx, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas fengycin B contains D-Val instead of D-Ala.

Application

Fengycin may be used for the sterilization of E. coli., and for the inactivation of spores of Bacillus cereus.

Actions biochimiques/physiologiques

Fengycin shows antifungal properties against filamentous fungi, but has no action against yeast and bacteria. Certain unsaturated fatty acids facilitate the antifungal property, whereas sterols, phospholipids and oleic acid act as antagonists. It produces morphological abnormalities in fungi including curling, bulging and empyting of hyphae. Thus, it mainly functions through its effects on the plasma membrane.

Conditionnement

5MG

Stockage et stabilité

Store at 2 to 8 °C. (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Les clients ont également consulté

Antifungal effects of bacilysin and fengymycin from Bacillus subtilis F-29-3 a comparsion with activities of other Bacillus antibiotics.
Loeffler W., et al
Journal of Phytopathology, 115, 204-213 (1986)
Marc Ongena et al.
Environmental microbiology, 9(4), 1084-1090 (2007-03-16)
Multiple strains of Bacillus spp. were demonstrated to stimulate plant defence responses. However, very little is known about the nature of molecular determinants secreted by these Gram-positive bacteria that are responsible for the elicitation of the induced systemic resistance (ISR)
N Vanittanakom et al.
The Journal of antibiotics, 39(7), 888-901 (1986-07-01)
Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi but is ineffective against yeast and bacteria. The inhibition is antagonized by sterols, phospholipids and oleic acid, whereas two other unsaturated fatty acids increase
Optimization of sterilization of Escherichia coli in milk by surfactin and fengycin using a response surface method.
Huang X
Current Microbiology, 56(4), 376-381 (2008)
Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67
Nishikiori, T., et al
The Journal of Antibiotics, 39, 745-745 (1986)

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