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Key Documents

SAB4502244

Sigma-Aldrich

Anti-CYTL1 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

C4orf4, Cytokine-like protein 1, Protein C17

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 15 kDa

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q9NRR1

Numéro d'accès UniProt

Q9NRR1

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CYTL1(54360)

Description générale

Anti-CYTL1 antibody detects endogenous levels of total CYTL1 protein.
The CYTL1 (cytokine like 1) gene is mapped to human chromosome 4p16.2. The gene was first discovered in CD34(+) cells of the bone marrow and cord blood. The encoded protein is predominantly expressed in chondrocytes.

Immunogène

The antiserum was produced against synthesized peptide derived from human CYTL1.

Immunogen Range: 61-110

Actions biochimiques/physiologiques

In vitro studies reveal that Cytl1 (cytokine like 1) acts as an autocrine or paracrine regulatory factor in the process of cartilage formation. CYTL1, being homologous with IL-2 (interleukin-2), is considered as a potential cytokine that is involved in regulating immune responses. CYTL1 is known to be associated with the pathogenesis of rheumatoid arthritis and osteoarthritis.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Wang X
Journal of Immunology, 196(10), 4090-4099 (2016)
Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model.
Tomczak A
Proteins: Structure, Function, and Genetics, 79(4), 1277-1292 (2011)
Tanja Vukićević et al.
Journal of the American Society of Nephrology : JASN, 30(5), 795-810 (2019-04-17)
Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. This pathway fine-tunes renal water reabsorption and urinary concentration, and its perturbation
Xiaolin Wang et al.
Oncoimmunology, 8(5), e1577126-e1577126 (2019-05-10)
CYTL1 is a novel cytokine that was first identified in CD34+ hematopoietic cells. We previously prepared recombinant CYTL1 and verified that it chemoattracted human monocytes via the CCR2/ERK pathway. It has been reported that CYTL1 plays contradictory roles in neuroblastoma
C17 prevents inflammatory arthritis and associated joint destruction in mice.
Chao C
PLoS ONE, 6(7) (2011)
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