SAB4200412

Anti-PLAUR/uPAR antibody, Mouse monoclonal

clone PL231, purified from hybridoma cell culture

• Synonyme(s) : Anti-CD87, Anti-Plasminogen activator urokinase receptor, Anti-UPAR, Anti-URKR, Monoclonal Anti-PLAUR/uPAR antibody produced in mouse
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: purified from hybridoma cell culture
• Type de produit anticorps: primary antibodies
• Clone: PL231, monoclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~55 kDa
• Espèces réactives: monkey, rat, canine, human, mouse
• Validation améliorée: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentration: ~1.0 mg/mL
• Technique(s): indirect immunofluorescence: suitable; western blot: 4.0-8.0 μg/mL using extracts of HL-60 cells
• Isotype: IgG1
• Numéro d'accès UniProt: Q03405
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PLAUR(5329)

Description

Description générale

Plasminogen activator, urokinase receptor (PLAUR) is a well-characterized receptor for matrix-degrading proteases. It is encoded by the gene mapped to human chromosome 19q13.31.

Immunogène

peptide corresponding to a sequence at the C-terminus of human PLAUR/uPAR.

Application

Monoclonal Anti-PLAUR/uPAR antibody produced in mouse has been used in Western blotting (WB).[1]

Actions biochimiques/physiologiques

Plasminogen activator, urokinase receptor (PLAUR) plays a vital role in tumor cell invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is implicated in various normal and pathological processes. Elevated expression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Upregulated expression of PLAUR leads to the progression of kidney disease in children.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable