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Key Documents

SAB4300883

Sigma-Aldrich

Anti-NeuN antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

FLJ56884, FLJ58356, FOX3, HRNBP3, RBFOX3

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

34 kDa

Espèces réactives

human, mouse, rat

Concentration

1.0 mg/mL

Technique(s)

western blot: 1:500-1:2000 (Cell Lysate)

Isotype

IgG

Numéro d'accès

NP_001076044.1

Numéro d'accès UniProt

A6NFN3

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... RBFOX3(146713)

Description générale

NeuN (neuronal nuclei), also known as RBFOX3 (RNA binding protein, fox-1 homolog 3), is encoded by the gene mapped to human chromosome 17q25.3. The encoded protein belongs to the RBFOX family of proteins. NeuN is present in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system (CNS) of mammals.

Spécificité

The antibody detects endogenous level of total NeuN protein.

Immunogène

Recombinant protein of human NeuN.

Application

Anti-NeuN antibody produced in rabbit has been used in Immunohistochemical staining.

Actions biochimiques/physiologiques

NeuN (neuronal nuclei)/RBFOX3 (RNA binding protein, fox-1 homolog 3) is a RNA splicing factor. It controls neuronal splicing pathway. NeuN is used as a potential marker of postmitotic neurons in studies of neuronal differentiation and in the evaluation of neuronal status both in norm and pathology. Mutation in the gene is associated with risk of rolandic epilepsy. Studies have shown that in presence of neurological disorders, the protein is mislocalized.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts.
Li Y I, et al.
Genome Research, 25(1), 1-13 (2015)
RBFOX1 and RBFOX3 mutations in rolandic epilepsy.
Lal D, et al.
PLoS ONE, 8(9), e73323-e73323 (2013)
Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression.
Zhao J, et al.
Molecular Medicine Reports, 12(5), 6911-6917 (2015)
Effect of transplantation of olfactory ensheathing cell conditioned medium induced bone marrow stromal cells on rats with spinal cord injury.
Feng L, et al.
Molecular Medicine Reports, 16(2), 1661-1668 (2017)
ETV2 mediates endothelial transdifferentiation of glioblastoma.
Zhao C, et al.
Signal transduction and targeted therapy, 3(1), 4-4 (2018)
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