SAB4200685

Anti-Glucagon antibody, Mouse monoclonal

clone K79bB10, purified from hybridoma cell culture

• Synonyme(s) : Monoclonal Anti-Glucagon antibody produced in mouse, GCG, GLP1, GLP2, GRPP
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: K79bB10, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human
• Conditionnement: antibody small pack of 25 μL
• Concentration: ~1 mg/mL
• Technique(s): immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin^®-Peroxidase staining system.; radioimmunoassay: suitable
• Isotype: IgG1
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: cat ... Gcg(101097825) ; dog ... Gcg(403571) ; guinea pig ... Gcg(100135526) ; human ... GCG(2641) ; mouse ... Gcg(14526) ; pig ... Gcg(397595) ; rabbit ... Gcg(100341777) ; rat ... Gcg(24952)

Description

Description générale

Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).

Immunogène

Polymerized porcine glucagon

Application

Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).

Actions biochimiques/physiologiques

The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Informations légales

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable