SAB4200678

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

• Synonyme(s) : Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 300
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: COL-1, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: pig, rat, human, deer, bovine
• Concentration: ~1 mg/mL
• Technique(s): ELISA: suitable; dot blot: suitable; immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum; immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue
• Isotype: IgG1
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... COL1A1(1277)

Description

Description générale

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.

Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogène

bovine skin collagen type I

Application

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Actions biochimiques/physiologiques

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.

Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable