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S1451

Sigma-Aldrich

Anti-Sox2 antibody, Mouse monoclonal

clone SOX2-6, purified from hybridoma cell culture

Synonyme(s) :

Anti-ANOP3, Anti-MCOPS3, Anti-SRY (sex determining region Y)-box 2, Anti-SRY-related HMG-box gene 2, Anti-Sex-determining region Y-box 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

SOX2-6, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~35 kDa

Espèces réactives

human, mouse

Concentration

~1.0 mg/mL

Technique(s)

western blot: 0.5-1.0 μg/mL using whole extract of human NT2 cells

Isotype

IgG1

Numéro d'accès UniProt

P48431

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)

Description générale

Monoclonal Anti-SOX2 (mouse IgG1 isotype) is derived from the hybridoma SOX2-6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acid. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.

Application

Anti-Sox2 antibody has been used in western blotting and immunohistochemistry.

Actions biochimiques/physiologiques

Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
060M4827
089K4801

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Mutations in SOX2 cause anophthalmia
Fantes J, et al.
Nature Genetics, 33(4), 462-462 (2003)
SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
Hussenet T, et al.
PLoS ONE, 5(1) (2010)
CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog
Nishii T, et al.
The Journal of Biological Chemistry, 287(15), 12417-12424 (2012)
Thais Fernanda de Almeida Galatro et al.
PloS one, 8(4), e61605-e61605 (2013-04-25)
Inhibitor of DNA Binding 4 (ID4) is a member of the helix-loop-helix ID family of transcription factors, mostly present in the central nervous system during embryonic development, that has been associated with TP53 mutation and activation of SOX2. Along with
CIBZ Regulates Mesodermal and Cardiac Differentiation of by Suppressing T and Mesp1 Expression in Mouse Embryonic Stem Cells
Kotoku T, et al.
Scientific Reports, 6 (2016)
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