P9297

Paromomycin sulfate salt

≥98% (TLC)

• Synonyme(s) : Aminosidine sulfate
• Formule empirique (notation de Hill): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• Numéro CAS: 1263-89-4
• Poids moléculaire : 615.63 (free base basis)
• Numéro Beilstein : 5715182
• Code UNSPSC : 51281663
• ID de substance PubChem : 24278662
• Nomenclature NACRES : NA.85

Propriétés

• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; parasites
• Mode d’action: protein synthesis | interferes
• Chaîne SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• Clé InChI: OYJABWUHUYVDMJ-UDXJMMFXSA-N

Description

Description générale

Chemical structure: aminoglycoside

Application

Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative bacteria, Gram-positive bacteria, some protozoan species, and limited antihelminth.
It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit Cryptosporidium infection of a human enterocyte cell line.

Actions biochimiques/physiologiques

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Conditionnement

1g,5g,25g

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable