O4126

Oxaloacetic acid

≥97% (HPLC)

• Synonyme(s) : 2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid
• Formule linéaire : HOOCCH₂COCOOH
• Numéro CAS: 328-42-7
• Poids moléculaire : 132.07
• UNSPSC Code: 12352204
• NACRES: NA.32
• PubChem Substance ID: 24897993
• EC Number: 206-329-8
• Beilstein/REAXYS Number: 1705475
• MDL number: MFCD00002592

Propriétés

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• solubility: H₂O: 100 mg/mL, clear to slightly hazy, colorless to light yellow
• storage temp.: −20°C
• SMILES string: OC(=O)CC(=O)C(O)=O
• InChI: 1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)
• InChI key: KHPXUQMNIQBQEV-UHFFFAOYSA-N

Description

General description

Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.

Application

Oxaloacetic acid has been used as a substrate for measuring citrate synthase activity in cybrids and neuroblastoma cells. It has also been used for measuring malate dehydrogenase reactivation.

Biochem/physiol Actions

Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges