P5780

Putrescine dihydrochloride

powder, BioReagent, suitable for cell culture

• Synonyme(s) : 1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tétraméthylènediamine dihydrochloride
• Formule linéaire : NH₂(CH₂)₄NH₂ · 2HCl
• Numéro CAS: 333-93-7
• Poids moléculaire : 161.07
• UNSPSC Code: 12352207
• NACRES: NA.75
• PubChem Substance ID: 24898707
• EC Number: 206-375-9
• Beilstein/REAXYS Number: 3906680
• MDL number: MFCD00012526
• Assay: ≥97% (TLC)
• Form: powder

Propriétés

• Quality Segment: 200
• biological source: microbial, synthetic
• product line: BioReagent
• assay: ≥97% (TLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 280 °C (dec.) (lit.)
• solubility: H₂O: 100 mg/mL
• SMILES string: Cl[H].Cl[H].NCCCCN
• InChI: 1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
• InChI key: XXWCODXIQWIHQN-UHFFFAOYSA-N

Description

General description

Listen to an Audio Overview
Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Application

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

Biochem/physiol Actions

Se fixe au site de modulation par la polyimine du récepteur du NMDA et potentialise les courants induits par le NMDA ; précurseur de la spermidine.

Se fixe au site de modulation par la polyimine du récepteur du NMDA ; potentialise les courants induits par le NMDA.

Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS05
• Mot-clé: Danger
• Codes de danger: H302,H311,H314,H330
• Mentions de précaution: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Que se passe-t-il ?: WGK 1
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves
• Point d'éclair (°F): 113.0 °F - closed cup
• Point d'éclair (°C): 45 °C - closed cup