P1372

Paroxetine maleate salt

≥98% (HPLC), Selective serotonin reuptake inhibitor, solid

• Synonyme(s) : (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt, BRL-29060, FG-7051
• Formule empirique (notation de Hill) : C₁₉H₂₀FNO₃ · C₄H₄O₄
• Numéro CAS: 64006-44-6
• Poids moléculaire : 445.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 329820091
• NACRES: NA.77
• MDL number: MFCD01742665
• Assay: ≥98% (HPLC)
• Form: solid

Propriétés

• Nom du produit: Paroxetine maleate salt, ≥98% (HPLC), solid
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: ~12 mg/mL, H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C=C/C(O)=O.Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3
• InChI: 1S/C19H20FNO3.C4H4O4/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;5-3(6)1-2-4(7)8/h1-6,9,14,17,21H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,17-;/m0./s1
• InChI key: AEIUZSKXSWGSRU-QXGDPHCHSA-N
• Gene Information: human ... SLC6A4(6532)

Description

Biochem/physiol Actions

Paroxetine maleate is a selective serotonin reuptake inhibitor; antidepressant.

Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold with the permission of Glaxo­Smith­Kline

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves