P0778

Pindolol

≥98% (TLC), powder

• Synonyme(s) : 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
• Formule empirique (notation de Hill): C₁₄H₂₀N₂O₂
• Numéro CAS: 13523-86-9
• Poids moléculaire : 248.32
• Numéro CE : 236-867-9
• Numéro MDL: MFCD00010530
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277795
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 167-171 °C (lit.)
• Solubilité: 0.1 M NaOH: 0.2 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL; 0.1 M HCl: 20 mg/mL; acetic acid: 50 mg/mL; H₂O: insoluble
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)NCC(O)COc1cccc2[nH]ccc12
• InChI: 1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
• Clé InChI: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRB1(153) , ADRB2(154) , HTR1A(3350)

Description

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Actions biochimiques/physiologiques

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

Caractéristiques et avantages

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves