P0440

Pimaricin preparation

~2.5% (γ-irradiated Pimaricin), aqueous suspension

• Synonyme(s) : Pimaricin, Tennecetin, Natamycin preparation
• Formule empirique (notation de Hill): C₃₃H₄₇NO₁₃
• Numéro CAS: 7681-93-8
• Poids moléculaire : 665.73
• Beilstein: 1614878
• Numéro MDL: MFCD00135085
• Code UNSPSC : 51102829
• ID de substance PubChem : 24898105
• Nomenclature NACRES : NA.85

Propriétés

• Forme: aqueous suspension
• Niveau de qualité: 200
• Concentration: ~2.5% (γ-irradiated Pimaricin)
• Solubilité: DMSO: soluble
• Densité: 1.0 g/mL at 20 °C (lit.)
• Spectre d'activité de l'antibiotique: fungi; yeast
• Mode d’action: cell membrane | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: [H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C[C@@H](C)OC(=O)\C=C\[C@@]4([H])O[C@]4([H])C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
• InChI: 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
• Clé InChI: NCXMLFZGDNKEPB-FFPOYIOWSA-N

Description

Description générale

This product is a saline suspension with approximately 2.5% pimaricin γ-irradiated.

Pimaricin is a polyene antifungal antibiotic produced by Streptomyces natalensis from soil near Pietermaritzburg, South Africa.¹ Pimaricin has antimicrobial activity similar to that of nystatin. In addition, it is active against Trichomonas vaginalis. Pimaricin is used in the treatment of candidiasis, trichomoniasis, fungal keratitis and aspergillosis. It has also been used as a food additive in some countries. In some studies, it has been shown to decrease the amount of mold upon which the Dermatophagoides pteronyssinus (house-dust mite) is dependent.²

Application

Pimaricin is an amphoteric antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis[1] and as a fungicide in agar media[2].

Actions biochimiques/physiologiques

An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nystatin and filipin, pimaricin does not change the permeability of the plasma membrane.

Notes préparatoires

The product can be further diluted with 0.5 M sodium chloride giving a suspension as well. The product can also be further diluted into an organic solvent such as dimethylformamide (may also be soluble in DMSO).

The product and any aqueous dilutions will be suspensions and should not be sterile filtered.

Stockage et stabilité

The product is not degraded by a single freeze-thaw cycle. The diluted product should be aliquoted and stored frozen.

Autres remarques

20ml

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Light Sensitive

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves