N216
Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse
clone C2C12
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About This Item
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Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Type de produit anticorps
primary antibodies
Clone
C2C12, monoclonal
Forme
liquid
Poids mol.
antigen 120 kDa (mature exchanger)
antigen 160 kDa (non-reduced)
antigen 70 kDa (proteolytic fragment)
Espèces réactives
human, rat, canine, rabbit, guinea pig
Technique(s)
immunohistochemistry (frozen sections): 1:200
immunoprecipitation (IP): suitable
western blot: 1:1,000
Isotype
IgM
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Informations sur le gène
human ... SLC8A1(6546)
Description générale
Na+/Ca2+ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.
Spécificité
The antibody reacts specifically with Na+/Ca2+ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues.
Immunogène
dog cardiac Na+/Ca2+ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane.
Actions biochimiques/physiologiques
Na+/Ca2+ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca2+ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na+ or Ca2+.
Forme physique
Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Julian Vallejo et al.
PloS one, 11(3), e0150066-e0150066 (2016-03-10)
There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects
Hanxing Wan et al.
Oncogene, 41(35), 4169-4182 (2022-07-27)
Plasma membrane Na+/Ca2+ exchanger 1 (NCX1) is a bidirectional ion transporter to operate in Ca2+ entry or exit modes, and TRPC1 is Ca2+-permeable channel. Both NCX1 and TRPC1 play critical roles in maintaining cytosolic free Ca2+ ([Ca2+]cyt) homeostasis in mammalian
Jia Chang et al.
The Journal of biological chemistry, 282(42), 30938-30948 (2007-08-28)
Mesenchymal stem cells (MSCs) are multipotent cells that can be differentiated into osteoblasts and provide an excellent cell source for bone regeneration and repair. Recently, the canonical Wnt/beta-catenin signaling pathway has been found to play a critical role in skeletal
Ping-Chun Li et al.
PloS one, 9(2), e85909-e85909 (2014-02-06)
Levosimendan, a known calcium sensitizer with positive inotropic and vasodilating properties, might also be cardioprotective during ischemia-reperfusion (I/R) insult. Its effects on calcium homeostasis and apoptosis in I/R injury remain unclear. Na(+)/Ca(2+) exchanger (NCX) is a critical mediator of calcium
Wakam Chang et al.
Nucleus (Austin, Tex.), 6(1), 77-88 (2015-01-15)
Myoblast migration is essential for muscle development and repair; however, the factors that contribute to the polarity of migrating myoblasts are relatively unknown. We find that randomly migrating C2C12 myoblasts orient their centrosomes in the direction of migration. Using wounded
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