Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

M4145

Sigma-Aldrich

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

Synonyme(s) :

6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C9H15N5O
Numéro CAS:
38304-91-5
Poids moléculaire :
209.25
Numéro CE :
253-874-2
Numéro MDL:
MFCD00063409
Code UNSPSC :
12352200
ID de substance PubChem :
24277853
Nomenclature NACRES :
NA.77

product name

Minoxidil, ≥99% (TLC)

Pureté

≥99% (TLC)

Pf

272-274 °C (dec.) (lit.)

Auteur

Johnson & Johnson

Chaîne SMILES 

NC1=CC(=NC(=N)N1O)N2CCCCC2

InChI

1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2

Clé InChI

ZIMGGGWCDYVHOY-UHFFFAOYSA-N

Informations sur le gène

human ... KCNJ1(3758)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Application

Minoxidil has been used as test drug:
  • in dermal papilla spheroid model, to study the effect of hair regeneration
  • administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
  • administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Actions biochimiques/physiologiques

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.
Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Caractéristiques et avantages

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 5

1 of 5

Finasteride British Pharmacopoeia (BP) Reference Standard

BP740

Finasteride

Cromakalim

Sigma-Aldrich

C1055

Cromakalim

Rilmenidine hemifumarate salt solid

Sigma-Aldrich

R134

Rilmenidine hemifumarate salt

2,6-Diamino-4-chloropyrimidine 98%

Sigma-Aldrich

C33204

2,6-Diamino-4-chloropyrimidine

Dutasteride United States Pharmacopeia (USP) Reference Standard

USP

1229922

Dutasteride

Stefan Sarkovich et al.
Journal of experimental orthopaedics, 10(1), 84-84 (2023-08-22)
Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri-operative function, we evaluated the antifibrotic effect of Minoxidil (MXD) on formation of pyridinoline
Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Gupta AC, et al.
Journal of Cellular Physiology, 233(11), 9015-9030 (2018)
J van der Velden et al.
Cellular and molecular life sciences : CMLS, 55(5), 788-798 (1999-06-24)
To investigate whether during cardiac hypertrophy changes occur in contractile protein composition and in mechanical and energetic properties of the myocardium, contractile protein composition, isometric force and adenosine triphosphate (ATP) consumption were studied in control and hypertrophied guinea-pig hearts. Cardiac
J I Kourie
The Journal of membrane biology, 164(1), 47-58 (1998-06-24)
The lipid bilayer technique was used to examine the effects of the ATP-sensitive K+ channel inhibitor (glibenclamide) and openers (diazoxide, minoxidil and cromakalim) and Cl- channel activators (GABA and diazepam) on two types of chloride channels in the sarcoplasmic reticulum
Ilaria Aurigemma et al.
Biochemical and biophysical research communications, 720, 150104-150104 (2024-05-16)
The T-BOX transcription factor TBX1 is essential for the development of the pharyngeal apparatus and it is haploinsufficient in DiGeorge syndrome (DGS), a developmental anomaly associated with congenital heart disease and other abnormalities. The murine model recapitulates the heart phenotype
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique