L6250

Lithocholic acid

≥95%

• Synonyme(s) : 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
• Formule empirique (notation de Hill) : C₂₄H₄₀O₃
• Numéro CAS: 434-13-9
• Poids moléculaire : 376.57
• UNSPSC Code: 12352106
• NACRES: NA.25
• PubChem Substance ID: 24896429
• EC Number: 207-099-1
• Beilstein/REAXYS Number: 3217757
• MDL number: MFCD00003682

Propriétés

• biological source: bovine bile
• Quality Segment: 200
• assay: ≥95%
• mol wt: 376.57 g/mol
• mp: 183-188 °C (lit.)
• functional group: carboxylic acid
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC(O)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1
• InChI key: SMEROWZSTRWXGI-HVATVPOCSA-N
• Gene Information: human ... POLA1(5422), TOP2A(7153) ; rat ... Polb(29240)

Description

General description

Lithocholic acid is an oligo(ethylene glycol) derivative of bile acid.

Application

Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ.

Biochem/physiol Actions

Bile Acid

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)