L5647

Lidocaine hydrochloride monohydrate

≥99% (HPLC), solid, Na⁺ channel blocker

• Synonyme(s) : 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
• Formule empirique (notation de Hill) : C₁₄H₂₂N₂O · HCl · H₂O
• Numéro CAS: 6108-05-0
• Poids moléculaire : 288.81
• NACRES: NA.77
• PubChem Substance ID: 24277718
• UNSPSC Code: 12352200
• EC Number: 200-803-8
• MDL number: MFCD00150329
• Form: solid

Propriétés

• Nom du produit: Lidocaine hydrochloride monohydrate, solid
• form: solid
• Quality Segment: 200
• color: white
• solubility: H₂O: soluble
• SMILES string: Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
• InChI key: YECIFGHRMFEPJK-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.

Application

Lidocaine hydrochloride monohydrate has been used:

• in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
• to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
• For inhibition of glial cells in brain tissue samples.

Biochem/physiol Actions

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration

Na⁺ channel blocker; class IB antiarrhythmic.

Informations sur la sécurité

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• Hazard Classifications: Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• pcodes: P264 - P270 - P301 + P310 - P405 - P501