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L4021

Sigma-Aldrich

Prolactin human

recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)

Synonyme(s) :

hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL

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About This Item

Numéro CAS:
9002-62-4
Numéro MDL:
MFCD00131553
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77

Produit recombinant

expressed in E. coli

Niveau de qualité

200

Description

200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).

Gamme de produits

BioReagent

Pureté

>97% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.030-0.300 ng/mL EC50

Poids mol.

predicted mol wt ~24 kDa

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Solubilité

water: 0.5000 mL, clear, colorless

Numéro d'accès UniProt

P01236

Conditions d'expédition

ambient

Température de stockage

−20°C

Informations sur le gène

human ... PRL(5617)

Application

Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.

Actions biochimiques/physiologiques

Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Autres remarques

Contains an N-terminal methionine not present in the natural product.

Forme physique

Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.

Reconstitution

It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.

Remarque sur l'analyse

The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360

Conseils de prudence

P201 - P308 + P313

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
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