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I8904

Sigma-Aldrich

Insulin-like Growth Factor-II from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonyme(s) :

IGF-II

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About This Item

Numéro MDL:
MFCD00241895
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Insulin-like Growth Factor-II from mouse, IGF-II, recombinant, expressed in E. coli, lyophilized powder

Source biologique

mouse

Produit recombinant

expressed in E. coli

Pureté

>97% (SDS-PAGE)

Forme

lyophilized powder

Qualité

endotoxin tested

Poids mol.

~7.4 kDa

Conditionnement

pkg of 5X50 μg
pkg of 50 μg

Impuretés

<1.0EUper1mg (LAL test)

Numéro d'accès UniProt

P09535

Température de stockage

−20°C

Informations sur le gène

mouse ... IGF2(16002) , Igf2(16002)

Description générale

Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions.

Actions biochimiques/physiologiques

Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney.

Forme physique

Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA.

Remarque sur l'analyse

The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7.

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Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in mouse, clone 75014, purified immunoglobulin, lyophilized powder

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Biyun Qian et al.
Oncology reports, 25(1), 203-213 (2010-11-27)
High expression of insulin-like growth factor-II (IGF-II) in epithelial ovarian cancer is associated with aggressive disease and poor prognosis. IGF-II transcription is initiated from multiple promoters. Promoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer. Here
S D O'Dell et al.
The international journal of biochemistry & cell biology, 30(7), 767-771 (1998-09-02)
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I. The liver is the
Shuo Chen et al.
Cell reports, 32(6), 108007-108007 (2020-08-14)
Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis. However, the niche cells supporting mesenchymal stem cells (MSCs) are largely unknown. Using

Articles

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