E9406

Epirubicin hydrochloride

≥90% (HPLC)

• Synonyme(s) : 4′-Epidoxorubicin hydrochloride, Epidoxorubicin hydrochloride
• Formule empirique (notation de Hill) : C₂₇H₂₉NO₁₁ · HCl
• Numéro CAS: 56390-09-1
• Poids moléculaire : 579.98
• NACRES: NA.85
• PubChem Substance ID: 329799084
• UNSPSC Code: 51102829
• EC Number: 260-145-2
• MDL number: MFCD00941448

Propriétés

• biological source: synthetic
• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• color: red to deep red
• solubility: H₂O: soluble
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: −20°C
• SMILES string: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-FGBSZODSSA-N

Description

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Biochem/physiol Actions

Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mot-clé: Danger
• Codes de danger: H302,H340,H350,H360
• Mentions de précaution: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 3
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves