Single-use aliquots of the stock solution are expected to remain stable for approximately 2 months stored at -20 °C.
D8893
Dexaméthasone
powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)
Synonyme(s) :
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-méthylpregna-1,4-diène-3,20-dione, 9α-Fluoro-16α-méthyl-11β,17α,21-trihydroxy-1,4-pregnadiène-3,20-dione, 9α-Fluoro-16α-méthylprednisolone, Prednisolone F
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A propos de cet article
Formule empirique (notation de Hill) :
C22H29FO5
Numéro CAS:
Poids moléculaire :
392.46
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥80% (HPLC)
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Laissez-nous vous aiderbiological source
synthetic (organic)
Quality Segment
sterility
γ-irradiated
product line
BioXtra
assay
≥80% (HPLC)
form
powder
potency
4-500 ng/mL
technique(s)
cell culture | mammalian: suitable
mp
262-264 °C (lit.)
solubility
ethanol: 1 mL/vial, clear
shipped in
ambient
storage temp.
2-8°C
SMILES string
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key
UREBDLICKHMUKA-CXSFZGCWSA-N
Gene Information
human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
Application
Biochem/physiol Actions
Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV). Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins. It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.
Agent anti-inflammatoire du type glucocorticoïde
Agent anti-inflammatoire du type glucocorticoïde. Régule la survie, la croissance et la différenciation des lymphocytes T. Inhibe l′induction de l′oxyde nitrique synthase.
Physical form
powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Preparation Note
To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
1 of 1
Cet article | |||
|---|---|---|---|
| description powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC) | description powder, BioReagent, suitable for cell culture, ≥97% | description ≥98% (HPLC), powder | description meets USP testing specifications |
| biological source synthetic (organic) | biological source synthetic | biological source - | biological source synthetic (organic) |
| assay ≥80% (HPLC) | assay ≥97% | assay ≥98% (HPLC) | assay 97.0-102.0% |
| product line BioXtra | product line BioReagent | product line - | product line - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| technique(s) cell culture | mammalian: suitable | technique(s) single cell analysis: suitable, cell culture | mammalian: suitable | technique(s) - | technique(s) - |
| form powder | form powder | form powder | form solid |
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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What is the shelf-life of 20ug/mL stock solution prepared in ethanol and media at -20C?
1 answer-
Helpful?
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What is the solubility of Product D8893, Dexamethasone, in DMSO?
1 answer-
The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.
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What solution stability information do you have available for Product D8893, Dexamethasone?
1 answer-
We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the best way to dissolve Product D8893, Dexamethasone?
1 answer-
The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).
Helpful?
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How do the dexamethasone products D8893 and the D4902 compare?
1 answer-
They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.
Helpful?
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What is the solubility of Product D8893, Dexamethasone, in ethanol?
1 answer-
The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.
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