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Key Documents

C7291

Sigma-Aldrich

Clomipramine hydrochloride

≥98% (HPLC), powder

Synonyme(s) :

3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride

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About This Item

Formule empirique (notation de Hill):
C19H23ClN2 · HCl
Numéro CAS:
Poids moléculaire :
351.31
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352116
ID de substance PubChem :
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

H2O: 25 mg/mL
0.1 M HCl: soluble

Auteur

Novartis

Chaîne SMILES 

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

Clé InChI

WIMWMKZEIBHDTH-UHFFFAOYSA-N

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Description générale

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

Application

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.
Clomipramine hydrochloride has been used:
  • to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
  • to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
  • as a serotonin reuptake inhibitor
  • as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

Actions biochimiques/physiologiques

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.
Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazardExclamation markEnvironment

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

Organes cibles

Central nervous system, Central nervous system,Cardiovascular

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves


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Consulter la Bibliothèque de documents

Genotoxic effect of the tricyclic antidepressant drug clomipramine hydrochloride in somatic and germ cells of male mice
El-Fiky SA, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 6(4), 321-327 (2016)
Novel therapeutic drug identification and gene correlation for fatty liver disease using high-content screening: Proof of concept
Luo Wei-Jia, et al.
European Journal of Pharmaceutical Sciences, 121, 106-117 (2018)
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
Koszela J, et al.
BMC biology, 16(1), 88-88 (2018)
Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats
Jimenez AG, et al.
Physiological Reports, 6(9), e13615-e13615 (2018)
Thammarat Aree
Pharmaceuticals (Basel, Switzerland), 13(10) (2020-10-03)
Depression is a global threat. Tricyclic antidepressants (TCAs) are still efficacious in treating depression, albeit with more side effects. Cyclodextrins (CDs) with a suitable nanocavity are potential drug carriers and can enhance the drug bioavailability. Aiming for an atomistic understanding

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