C6022

Cyproheptadine hydrochloride sesquihydrate

≥98% (TLC), solid

• Synonyme(s) : Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)
• Formule empirique (notation de Hill): C₂₁H₂₁N·HCl·1.5H₂O
• Numéro CAS: 41354-29-4
• Poids moléculaire : 350.88
• Numéro CE : 213-535-1
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278082
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (TLC)
• Forme: solid
• Couleur: white to slightly yellow
• Solubilité: ethanol: soluble; methanol: soluble
• Auteur: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Chaîne SMILES: Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
• InChI: 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
• Clé InChI: ZEAUHIZSRUAMQG-UHFFFAOYSA-N
• Informations sur le gène: human ... HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Description

Application

Cyproheptadine hydrochloride sesquihydrate has been used in:

• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
• the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)

Actions biochimiques/physiologiques

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.

Caractéristiques et avantages

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves