C5776

Cocaine hydrochloride

CNS stimulator, powder

• Synonyme(s) : Ecgonine methyl ester benzoate hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₂₁NO₄ · HCl
• Numéro CAS: 53-21-4
• Poids moléculaire : 339.81
• NACRES: NA.77
• PubChem Substance ID: 329775099
• UNSPSC Code: 12352200
• EC Number: 200-167-1
• MDL number: MFCD00058119
• Form: powder

Propriétés

• Nom du produit: Cocaine hydrochloride,
• form: powder
• Quality Segment: 200
• drug control: USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal), kontrollierte Droge in Deutschland
• application(s): forensics and toxicology
• SMILES string: Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
• InChI: 1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
• InChI key: PIQVDUKEQYOJNR-VZXSFKIWSA-N

Description

Application

Cocaine hydrochloride has been used:

• in saline control to study the effects of cocaine self-administration in mouse brain
• as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)
• to examine conditioning to intravenous cocaine hydrochloride

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Inhibits the dopamine, norepinephrine, and serotonin transporters.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Informations sur la sécurité

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H330,H336,H361d
• pcodes: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges