C4397

Chlorzoxazone

• Synonyme(s) : 5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole
• Formule empirique (notation de Hill): C₇H₄ClNO₂
• Numéro CAS: 95-25-0
• Poids moléculaire : 169.57
• Numéro CE : 202-403-9
• Numéro MDL: MFCD00005717
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277702
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 191-192 °C (lit.)
• Solubilité: DMSO: 50 mg/mL, clear
• Auteur: Johnson & Johnson
• Température de stockage: room temp
• Chaîne SMILES: Clc1ccc2OC(=O)Nc2c1
• InChI: 1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
• Clé InChI: TZFWDZFKRBELIQ-UHFFFAOYSA-N
• Informations sur le gène: human ... KCNN4(3783)

Description

Application

Chlorzoxazone may be used:

• as a calcium-activated potassium (K_Ca) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability
• as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes
• as a benzimidazolone compound to test its effect on epithelial sodium (Na⁺) transport

Actions biochimiques/physiologiques

Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas. It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice. Chlorzoxazone also activates the calcium-activated potassium (K_Ca) channel and small conductance calcium-activated potassium channels (SK). It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function.

Chlorzoxazone is a skeletal muscle relaxant.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves