C3993

Carvedilol

≥98% (HPLC), solid

• Synonyme(s) : 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190
• Formule empirique (notation de Hill): C₂₄H₂₆N₂O₄
• Numéro CAS: 72956-09-3
• Poids moléculaire : 406.47
• Numéro MDL: MFCD00864692
• Code UNSPSC : 12352200
• ID de substance PubChem : 329775050
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: DMSO: >20 mg/mL
• Auteur: GlaxoSmithKline
• Chaîne SMILES: OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
• InChI: 1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
• Clé InChI: OGHNVEJMJSYVRP-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Description

Application

Carvedilol has been used:

• as a β blocker to determine its effect on hypoxia inducible factor (HIF)-mediated erythropoiesis under hypoxia in vivo
• as a βAR antagonist for inhibition of bARs
• as a β-blocker to examine airway mechanics in fungus-challenged mice

Actions biochimiques/physiologiques

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Caractéristiques et avantages

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H373,H411
• Conseils de prudence: P260 - P273 - P314 - P391 - P501
• Classification des risques: Aquatic Chronic 2 - STOT RE 2
• Organes cibles: Liver,spleen,Uterus (including cervix),Adrenal gland
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves