A0606

Aurothioglucose hydrate

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

• Synonyme(s) : Gold thioglucose, Solganal, Solganol
• Formule empirique (notation de Hill) : C₆H₁₁AuO₅S · xH₂O
• Numéro CAS: 12192-57-3
• Poids moléculaire : 392.18 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724383
• NACRES: NA.77
• EC Number: 235-365-7
• Assay: ≥96% (titration)
• Form: powder
• Storage condition: desiccated

Propriétés

• Nom du produit: Aurothioglucose hydrate, ≥96% (titration)
• Quality Segment: 100
• assay: ≥96% (titration)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1
• InChI key: SGVIEHTYEMEDRR-PKXGBZFFSA-M

Description

Application

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC₅₀ approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Potent PKCι-Par6 interaction inhibitor

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves