82890

Pyridoxamine-5′-phosphate

≥98.0% (HPLC)

• Synonyme(s) : 4-Aminomethyl-5-hydroxy-6-methyl-3-pyridylmethyl phosphate
• Formule empirique (notation de Hill): C₈H₁₃N₂O₅P
• Numéro CAS: 529-96-4
• Poids moléculaire : 248.17
• Numéro Beilstein : 233653
• Numéro CE : 208-471-6
• Numéro MDL: MFCD00023504
• Code UNSPSC : 12352116
• ID de substance PubChem : 57652936
• Nomenclature NACRES : NA.79

Propriétés

• Pureté: ≥98.0% (HPLC)
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: faint beige to light beige; white to light yellow
• Chaîne SMILES: Cc1ncc(COP(O)(O)=O)c(CN)c1O
• InChI: 1S/C8H13N2O5P/c1-5-8(11)7(2-9)6(3-10-5)4-15-16(12,13)14/h3,11H,2,4,9H2,1H3,(H2,12,13,14)
• Clé InChI: ZMJGSOSNSPKHNH-UHFFFAOYSA-N

Description

Description générale

Pyridoxamine is a derivative of vitamin B₆. Pyridoxamine is a water-soluble vitamin. Vitamin B₆ derivatives contain a core pyridine ring. Pyridoxaminecontains an amino methyl group at pyridine′s 4′ position.

Application

Pyridoxamine-5′-phosphate is suitable:

• in the enzymatic synthesis of cytidine diphosphate-4-keto-3, 6-dideoxyglucose
• as a substrate for pyridoxamine-5′-phosphate phosphatase activity assay
• as a substrate to characterize pyridoxine-5′-phosphate oxidase
• for the absorbance and fluorescence studies of properties of NaBH4-reduced glycogen phosphorylase b to probe the microenvironment of PMP residue
• as a substrate for characterization of pyridoxamine-phosphate transaminase(s) from various species and tissues

Actions biochimiques/physiologiques

Pyridoxal 5′-phosphate can be converted to pyridoxamine-5′-phosphate in the presence of (S)-α-methylbenzylamine (MBA) as the amine donor by using pyruvate transaminase as a biocatalyst. Pyridoxine 5′-phosphate and pyridoxamine 5′-phosphate are oxidized to pyridoxal 5′-phosphate (PLP) using flavin mononucleotide (FMN) as the immediate electron acceptor and oxygen as the ultimate electron acceptor by the E. coli enzyme pyridoxine (pyridoxamine) 5′-phosphate oxidase.

pK of pyridoxamine-5′-phosphate (pyridoxamine 5-phosphate, PAMP) in the singlet excited state has been evaluated by absorption and fluorescence spectral studies.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves