72309

Acide nicotinique

≥99.5% (HPLC)

• Synonyme(s) : Acide 3-picolinique, Acide pyridine-3-carboxylique, Facteur de prévention de la pellagre
• Formule empirique (notation de Hill): C₆H₅NO₂
• Numéro CAS: 59-67-6
• Poids moléculaire : 123.11
• Numéro Beilstein : 109591
• Numéro CE : 200-441-0
• Numéro MDL: MFCD00006391
• Code UNSPSC : 12352209
• ID de substance PubChem : 57652411
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: synthetic
• Pureté: ≥99.5% (HPLC)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Impuretés: ≤0.2% water
• Résidus de calcination: ≤0.05%
• Couleur: colorless to white
• Pf: 234-238 °C; 236-239 °C (lit.)
• Solubilité: water: 0.1 g/10 mL, clear, colorless
• Densité: 1.473 g/cm³ at 25 °C
• Chaîne SMILES: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• Clé InChI: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Informations sur le gène: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

Description générale

Nicotinic acid, also referred as Niacin or vitamin B₃, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.

Application

Nicotinic acid has been used as a standard in NAD⁺ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.

Actions biochimiques/physiologiques

Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.

Autres remarques

Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 379.4 °F - closed cup
• Point d'éclair (°C): 193 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves