Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

53471

Sigma-Aldrich

FITC-CM-Dextran

average mol wt 70,000

Synonyme(s) :

FITC-CM-Dextran 70, Fluorescein isothiocyanate–Carboxymethyl–Dextran

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352116
Nomenclature NACRES :
NA.32

Conjugué

FITC conjugate

Forme

powder or crystals

Poids mol.

average mol wt 70,000

Composition

carboxymethyl content, 3-7%

Ampleur du marquage

0.001-0.020 mol/mol FITC glucose

Technique(s)

permeability assay: suitable

Fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Catégories apparentées

Description générale

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Application

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Yogy Simanjuntak et al.
PLoS pathogens, 16(5), e1008521-e1008521 (2020-05-12)
Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on
Reduced diffusion of charge-modified, conformationally intact anionic Ficoll relative to neutral Ficoll across the rat glomerular filtration barrier in vivo.
Axelsson J, Sverrisson K, Rippe A, et al.
American Journal of Physiology: Renal Physiology, 301, F708-F712 (2011)
Giulia Paci et al.
eLife, 9 (2020-07-22)
Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact. For these cargoes
Afficher tous les articles scientifiques apparentés

Articles

FITC-labelled polysaccharides

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

FITC-labelled polysaccharides

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

FITC-labelled polysaccharides

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

FITC-labelled polysaccharides

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique