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Merck
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Principaux documents

348M-9

Sigma-Aldrich

WT1 (6F-H2) Mouse Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

6F-H2, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (348M-94)
vial of 0.5 mL concentrate (348M-95)
bottle of 1.0 mL predilute (348M-97)
vial of 1.0 mL concentrate (348M-96)
bottle of 7.0 mL predilute (348M-98)

Fabricant/nom de marque

Cell Marque®

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotype

IgG1κ

Contrôle

kidney, mesothelioma, ovarian carcinoma (serous), testis

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Informations sur le gène

human ... WT1(7490)

Description générale

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed intissues of mesodermal origin. The Wilms’ tumor gene encodes a protein that functionsas a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma and thus isused as a marker for these neoplasms.

Qualité


IVD
IVD
IVD
RUO

Liaison

WT-1 Positive Control Slides, Product No. 348S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: [email protected]

Informations légales

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificats d'analyse (COA)

Lot/Batch Number
0000424985
0000422329
0000425408
0000422329
0000425408

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M Al-Hussaini et al.
Histopathology, 44(2), 109-115 (2004-02-07)
It has been suggested that WT-1 is helpful in distinguishing a primary ovarian serous carcinoma (OSC) from a primary uterine serous carcinoma (USC). Since both neoplasms are often disseminated at diagnosis and since USC often spreads to the ovary and
Alberto M Marchevsky
Archives of pathology & laboratory medicine, 132(3), 397-401 (2008-03-06)
The diagnosis of malignant mesothelioma (MM) is rendered with the aid of immunohistochemistry to demonstrate the presence of "mesothelial," "epithelial," or "sarcomatous" differentiation. Antibody panels that have been proposed for the distinction between MM and other neoplasms usually include 2
M A Ghanem et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(11), 4265-4271 (2000-12-06)
Wilms' tumor is one of the most common solid tumors of children. The protein product of the tumor-suppressor gene, Wilms' tumor 1 (WT-1), binds to the same DNA sequences as the protein product of the early growth response 1 (EGR-1)
Rena J May et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(15 Pt 1), 4547-4555 (2007-08-03)
Wilms' tumor 1 protein (WT1), a transcription factor overexpressed in malignant mesothelioma, leukemias, and other solid tumors, is an ideal target for immunotherapy. WT1 class I peptide epitopes that were identified and shown to stimulate CD8(+) T cells are being
R Barnoud et al.
The American journal of surgical pathology, 24(6), 830-836 (2000-06-08)
Desmoplastic small round cell tumors (DSRCTs) present a reciprocal chromosomal translocation, t(11;22)(p13;q12), that results in fusion of Ewing's sarcoma and Wilms' tumor (WT1) genes. The authors evaluated 15 DSRCTs and 71 other tumors often considered in the differential diagnosis for
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