17946

1α-Hydroxyvitamin D₃

≥97.0% (HPLC)

• Synonyme(s) : 1α-Hydroxycholecalciferol, Alfacalcidol
• Formule empirique (notation de Hill) : C₂₇H₄₄O₂
• Numéro CAS: 41294-56-8
• Poids moléculaire : 400.64
• NACRES: NA.79
• PubChem Substance ID: 57647693
• UNSPSC Code: 12352205
• EC Number: 255-297-1
• MDL number: MFCD00868328

Propriétés

• biological source: synthetic
• Quality Segment: 200
• assay: ≥97.0% (HPLC)
• form: powder or crystals
• color: white to off-white
• storage temp.: −20°C
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
• InChI: 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
• InChI key: OFHCOWSQAMBJIW-AVJTYSNKSA-N
• Gene Information: human ... VDR(7421)

Description

General description

1α-Hydroxyvitamin D₃, also known as alfacalcidol, is a synthetic vitamin D₃ analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

Biochem/physiol Actions

Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

1α-Hydroxyvitamin D₃ facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• hcodes: H300
• pictograms: GHS06
• signalword: Danger
• pcodes: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges