PHR1782

Hydroxychloroquine Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
• Formule empirique (notation de Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Numéro CAS: 747-36-4
• Poids moléculaire : 433.95
• Numéro CE : 212-019-3
• Numéro MDL: MFCD00078203
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823611
• Nomenclature NACRES : NA.24

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 300
• Qualité: certified reference material; pharmaceutical secondary standard
• Agence: BP; EP; USP; traceable to BP 1100; traceable to USP 1327000
• Famille d'API: hydroxychloroquine
• Forme: powder or crystals
• CofA (certificat d'analyse): current certificate can be downloaded
• Conditionnement: pkg of 1 g
• Conditions de stockage: protect from light
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Couleur: white to off-white
• pH: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• Pf: 238-241 °C
• Solubilité: chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble; water: soluble
• Application(s): pharmaceutical (small molecule)
• Conditions d'expédition: ambient
• Température de stockage: 2-30°C
• Chaîne SMILES: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• Clé InChI: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Informations sur le gène: human ... TLR7(51284) , TLR9(54106)

Description

Description générale

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Actions biochimiques/physiologiques

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAC0287 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319
• Conseils de prudence: P301 + P312 + P330 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable