If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
P1004
Polymyxine B sulfate salt
Synonyme(s) :
Polymixine, Polymyxine B, Sulfate de polymyxine B
About This Item
Produits recommandés
Source biologique
Pseudomonas aeruginosa
Niveau de qualité
Forme
powder
Conditions de stockage
(Tightly closed. Dry. )
Solubilité
water: 50 mg/mL
Spectre d'activité de l'antibiotique
Gram-negative bacteria
fungi
Mode d’action
cell membrane | interferes
Température de stockage
2-8°C
Chaîne SMILES
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
Clé InChI
HNDFYNOVSOOGDU-UHFFFAOYSA-N
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Description générale
Application
- Dans la culture de cellules endothéliales aortiques humaines (HAEC) afin d′exclure une éventuelle contamination par des endotoxines dans de l′adiponectine recombinante[1]
- Pour l′analyse d′isolats[2]
- Dans l′activité de neutralisation d′endotoxines de l′α-amylase (AmyI-1)-18 (test au LAL)[3]
Actions biochimiques/physiologiques
Spectre antimicrobien : Présente une action bactéricide vis-à-vis de la plupart des bacilles à Gram négatif††, notamment E. Coli et la plupart des champignons et des bactéries à Gram positif.
Caractéristiques et avantages
Notes préparatoires
Les solutions mères doivent être stérilisées par filtration et conservées entre 2 °C et 8 °C. Elles sont stables pendant 5 jours à 37 °C.
Stockage et stabilité
Autres remarques
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
Faites votre choix parmi les versions les plus récentes :
Certificats d'analyse (COA)
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Les clients ont également consulté
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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We're needing a little more information on how this product is sold. What size are the "units" that are mentioned, and can you provide any details as to the concentration of chemical in the unit? Thank you!
1 answer-
This product is sold by the International Unit (IU). The minimum activity of 6000 units per milligram is reported based on the dried weight of the powder. The maximum allowable moisture content at 7%. The amount of material in each vial varies from lot to lot and can be determined by dividing the number of units of the package size by the lot-specific activity. This information is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sial/p1004#product-documentationHelpful?
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Dear Sir, May I ask what's meaning of 10 MU? How many grams per bottle? Tks.
1 answer-
The 10 MU stands for a 10,000,000 unit package size. The mass contained in each bottle is lot-specific and dependent on the activity. This activity is reported on the certificate of analysis. For example, lot number 0000227415 tested at 8232 units per milligram. A 10 MU package size would amount to 1.214 grams. See the link below to review this Certificate of Analysis: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/P1004-50MU0000227415.pdf
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