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MABN77

Sigma-Aldrich

Anti-Potassium Channel Kv1.2 Antibody, clone K14/16

clone K14/16, from mouse

Synonyme(s) :

potassium voltage-gated channel, shaker-related subfamily, member 2, potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel subunit Kv1.2, Voltage-gated potassium channel HBK5, potassium channel, Voltage-gated K(+) channel

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

K14/16, monoclonal

Espèces réactives

rat

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

Isotype

IgG2bκ

Numéro d'accès NCBI

NP_037102

Numéro d'accès UniProt

P63142

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... KCNA2(3737)

Description générale

Potassium channel Kv1.2 is one of many different types of potassium channels in the cell. The Kv family of potassium channels seem to have a conserved homotetramer formation consisting of four voltage sensors and one pore domain. Kv1.2 cooperates with cortactin (an actin cytoskeleton-binding protein) and together they may have a part in the regulation of the ionic current.

Immunogène

Recombinant protein corresponding to rat Kv1.2.

Application

Immunofluorescence Analysis: a previous lot of this antibody was used by an independent laboratory in IF. (Yang, J.W., et al. (2007). PNAS. 104(50):20055–20060.)
This Anti-Potassium Channel Kv1.2 Antibody, clone K14/16 is validated for use in IH, WB, IF for the detection of Potassium Channel Kv1.2.

Qualité

Evaluated by Western Blot in rat brain membrane tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Kv1.2 on 10 µg of rat brain membrane tissue lysate.

Description de la cible

~ 65 kDa observed

Forme physique

Format: Purified

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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María T Dours-Zimmermann et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(24), 7731-7742 (2009-06-19)
The CNS-restricted versican splice-variant V2 is a large chondroitin sulfate proteoglycan incorporated in the extracellular matrix surrounding myelinated fibers and particularly accumulating at nodes of Ranvier. In vitro, it is a potent inhibitor of axonal growth and therefore considered to
De-En Xu et al.
Cell adhesion & migration, 8(4), 396-403 (2014-12-09)
Amyloid precursor protein (APP), commonly associated with Alzheimer disease, is upregulated and distributes evenly along the injured axons, and therefore, also known as a marker of demyelinating axonal injury and axonal degeneration. However, the physiological distribution and function of APP
Yoshinori Otani et al.
Communications biology, 3(1), 121-121 (2020-03-15)
Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy mainly caused by gene mutation of peripheral myelin proteins including myelin protein zero (P0, MPZ). Large myelin protein zero (L-MPZ) is an isoform of P0 that contains an extended polypeptide synthesized by translational
Du-Yu Nie et al.
The EMBO journal, 22(21), 5666-5678 (2003-11-01)
We report Nogo-A as an oligodendroglial component congregating and interacting with the Caspr-F3 complex at paranodes. However, its receptor Nogo-66 receptor (NgR) does not segregate to specific axonal domains. CHO cells cotransfected with Caspr and F3, but not with F3
O W Howell et al.
Brain : a journal of neurology, 129(Pt 12), 3173-3185 (2006-10-17)
Saltatory conduction in the nervous system is enabled through the intimate association between the leading edge of the myelin sheath and the axonal membrane to demarcate the node of Ranvier. The 186 kDa neuron specific isoform of the adhesion molecule
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