EZBRAIN42
Human Amyloid β42 ELISA Kit
measures and quantifies Amyloid β42 levels in 50 μL tissue or cell lysates
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About This Item
Code UNSPSC :
12161503
eCl@ss :
32161000
Nomenclature NACRES :
NA.77
Produits recommandés
product name
Human Amyloid β42 Brain ELISA, This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.
Niveau de qualité
Espèces réactives
human
Conditionnement
kit of 1 × 96 wells
Paramètres
50 μL sample volume (Overnight assay)
assay range
sensitivity: 8 pg/mL
(lowest level of Amyloid β1-42 standard; 50 μL sample size)
standard curve range: 16-500 pg/mL
Technique(s)
ELISA: suitable
Entrée
sample type tissue/cellular lysate
Application(s)
research use
Méthode de détection
colorimetric (450nm/590nm)
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Informations sur le gène
human ... APP(351)
Description générale
Amyloid beta peptides have been implicated in the etiology of Alzheimer’s disease. Amyloid beta 40 is the most prominent peptide and Amyloid beta 42 is the neurotoxic form. The Amyloid beta 42/40-ratio (AB ratio) has been reported as a better indicator of the Alzheimer pathology. Millipore’s Human Amyloid β42 Brain ELISA kit is used for the measurement of Amyloid beta 42 in brain samples and for other tissue samples in a 96-well format. This assay is for research use only and appropriate for the in vitro detection of human Amyloid β42 peptides in brain samples from e.g. Guinea pig, transgenic hAmyloid mice and cell extracts.
Spécificité
The Amyloid β42 ELISA uses monoclonal anti-Aβ antibodies with high selectivity for human Aβ. The capture antibody recognizes the C-terminal end of Amyloid β1-42, which causes a high selectivity for Aβ42. The cross-reactivity of the used antibodies to other Amyloid peptides was tested by ELISA and BIACORE and shows no significant cross-reactivity to Aβ1-38, Aβ1-39, Aβ1-42, Aβ1-43 and Aβ1-44.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Alzheimer′s Disease
Alzheimer′s Disease
This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.
This assay requires 50 µl of sample and is an overnight assay.
Used to detect/quantify: Amyloid β42
Stockage et stabilité
Components in the kit can be stored up to 2 weeks at 2-8°C
Autres remarques
Please contact Technical Service for linearity of dilution.
Clause de non-responsabilité
For research use only. Not for use in diagnostic procedures.
En option
Réf. du produit
Description
Tarif
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1
Code de la classe de stockage
8A - Combustible corrosive hazardous materials
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Jesse E Hanson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(24), 8277-8288 (2014-06-13)
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Y Goll et al.
Neuro-degenerative diseases, 13(2-3), 58-60 (2013-11-07)
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Elliott J Mufson et al.
Journal of neuropathology and experimental neurology, 71(11), 1018-1029 (2012-10-26)
Hippocampal precursor of nerve growth factor (proNGF)/NGF signaling occurs in conjunction with β-amyloid (Aβ) accumulations in Alzheimer disease (AD). To assess the involvement of this pathway in AD progression, we quantified these proteins and their downstream pathway activators in postmortem
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