8.40124

Span^® 85

for synthesis

• Synonyme(s) : Span^® 85, Sorbitan trioleate, (Z,Z,Z)-Sorbitan tri-9-octadecenoate
• Formule empirique (notation de Hill): C₆₀H₁₀₈O₈
• Numéro CAS: 26266-58-0
• Poids moléculaire : 957.49
• Numéro MDL: MFCD00133820
• Code UNSPSC : 12352108
• Numéro de classement CE : 247-569-3
• Nomenclature NACRES : NA.22

Propriétés

• Pression de vapeur: <1.4 hPa ( 20 °C)
• Niveau de qualité: 200
• Forme: liquid
• Puissance: 39800 mg/kg LD₅₀, oral (Rat)
• kinematic viscosity: 120 cSt(40 °C)
• Température de transition: flash point 225 °C
• Solubilité: insoluble <0.001 g/L
• Densité: 0.95 g/cm³ at 20 °C
• Température de stockage: 2-30°C
• InChI: 1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-53-55(67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2)60-59(54(61)52-66-60)68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27-/t54-,55?,59+,60-/m1/s1
• Clé InChI: PRXRUNOAOLTIEF-XDTJCZEISA-N

Description

Application

• Macromolecular Stabilization: Span^® 85 is used as a stabilizer for the preparation of PMMA colloidal particles in nonpolar media, proving effective in maintaining stability under various conditions, crucial for industrial applications in coatings and advanced materials manufacturing (Liu et al., 2022).


• Enhanced Nanoemulsion Systems: It plays a critical role in the formation of aerosolized nanoemulsion systems encapsulating docetaxel and curcumin, utilized in cancer therapy to improve therapeutic outcomes through enhanced drug delivery mechanisms (Abdul Rahman et al., 2020).


• Skin Protection Formulations: Span^® 85 is integral in the formulation and clinical assessment of microemulsion-based hydrogels for UV protection, demonstrating its utility in skincare products by enhancing sun protection factor and skin compatibility (Ebrahimi et al., 2019).


• Transdermal Drug Delivery: This surfactant is utilized in tailoring novel soft nano-vesicles, known as ′Flexosomes′, to enhance transdermal drug delivery, which is pivotal for non-invasive therapeutic applications and improving patient compliance (Mansour et al., 2019).

Remarque sur l'analyse

Hydroxyl value: 55 - 75
Saponification value: 170 - 190
Identity (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Informations légales

Span is a registered trademark of Croda International PLC

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 437.0 °F
• Point d'éclair (°C): 225 °C