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Key Documents

662047

Sigma-Aldrich

Anti-Uncoupling Protein-2 (UCP-2) (144-157) Rabbit pAb

liquid, Calbiochem®

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

liquid

Contient

0.1% sodium azide as preservative

Espèces réactives

human, mouse, rat

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
avoid repeated freeze/thaw cycles

Isotype

IgG

Conditions d'expédition

wet ice

Température de stockage

−70°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... UCP2(7351)

Description générale

Protein A purified rabbit polyclonal antibody. Recognizes the UCP-2 protein.
Recognizes the UCP-2 protein.

Immunogène

a synthetic peptide [(C)QARAGGGRRYQSTV] corresponding to amino acids 144-157 of human and mouse UCP-2

Application

ELISA (1:100,000)

Immunoblotting (1:1000)

Immunocytochemistry (1:500)

Conditionnement

Please refer to vial label for lot-specific concentration.

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Does not react with UCP-1 or UCP-3. Since this antigen sequence is highly conserved, cross-reactivity across a broad range of species is expected. Variables associated with assay conditions will dictate the proper working dilution.
Stuart, J.A., et al. 2001. J. Biol. Chem.276, 18633.
Gimeno, R.E., et al. 1997. Diabetes46, 900.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jay D Turner et al.
Circulation research, 106(4), 730-738 (2010-01-09)
Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated in pathological states such as heart failure. UCP2 is thought to protect cardiomyocytes against oxidative stress by dissipating the mitochondrial
P Brauner et al.
Pediatric research, 49(3), 440-447 (2001-03-03)
Hepatic hematopoiesis is prominent during fetal life and ceases around birth. In rodent liver, the decline of the hepatic hematopoiesis starts abruptly at birth being accompanied by a decrease of mitochondrial uncoupling protein 2 (UCP2) expression in monocytes/macrophages, whereas hepatocytes
Jan Ježek et al.
Antioxidants & redox signaling, 23(12), 958-972 (2015-05-01)
Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-mediated uncoupling attenuating mitochondrial superoxide
C Y Zhang et al.
Cell, 105(6), 745-755 (2001-07-07)
beta cells sense glucose through its metabolism and the resulting increase in ATP, which subsequently stimulates insulin secretion. Uncoupling protein-2 (UCP2) mediates mitochondrial proton leak, decreasing ATP production. In the present study, we assessed UCP2's role in regulating insulin secretion.
Yi-Hsieng Samuel Wu et al.
Journal of food and drug analysis, 29(2), 375-388 (2022-06-14)
This study aims to clarify the effects of chicken liver hydrolysates (CLHs) on long-term high-fat diet (HFD)-induced insulin resistance (IR) and hepatosteatosis in mice. In vitro, the 400 μM oleic acid (OA)-added medium successfully stimulated the cellular steatosis on FL83B
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