This product is a Certified Reference Material intended for use as an identification, calibration, and quantification standard. Unfortunately, a corresponding antibody is not available.
T-074
3,3′,5-Triiodo-L-thyronine (T3) solution
100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®
Synonyme(s) :
3,3′,5-Triiodo-L-thyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3
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About This Item
Formule empirique (notation de Hill):
C15H12I3NO4
Numéro CAS:
Poids moléculaire :
650.97
Beilstein:
2710227
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Qualité
certified reference material
Niveau de qualité
Forme
liquid
Caractéristiques
Snap-N-Spike®/Snap-N-Shoot®
Conditionnement
ampule of 1 mL
Fabricant/nom de marque
Cerilliant®
Concentration
100 μg/mL in methanol with 0.1N NH3
Technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
Pf
234-238 °C (lit.)
Application(s)
clinical testing
clinical testing
Format
single component solution
Température de stockage
−20°C
Chaîne SMILES
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
Clé InChI
AUYYCJSJGJYCDS-LBPRGKRZSA-N
Informations sur le gène
human ... THRA(7067) , THRB(7068)
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Description générale
Certified Spiking Solutions® are suitable for use as a starting material in the preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.
3,3′,5-Triiodo-L-thyronine (T3) is a thyroid hormone and active form of L-thyroxine (T4), formed by deiodinase type I or II. It supports various physiological functions, such as oxygen consumption, carbohydrate metabolism, protein synthesis, and neural development. Free and total T3 serum levels are measured by LC-MS/MS for the determination of hyperthyroidism caused by excess T3.
3,3′,5-Triiodo-L-thyronine (T3) is a thyroid hormone and active form of L-thyroxine (T4), formed by deiodinase type I or II. It supports various physiological functions, such as oxygen consumption, carbohydrate metabolism, protein synthesis, and neural development. Free and total T3 serum levels are measured by LC-MS/MS for the determination of hyperthyroidism caused by excess T3.
Application
The Certified Reference Material (CRM) in solution can also be used as follows:
- Multi-residue determination of seven thyroid hormones in placenta samples by isotope dilution liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS)
- Parts-per-trillion analysis of five thyroid hormones in zebrafish larvae by their solid phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray ionization- tandem mass spectrometric (UPLC-ESI/MS/MS) analysis
- Simultaneous analysis of six free thyroid hormones in bovine serum samples by ultrafiltration and high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS)
- Determination of six thyroid hormones in mouse tissue samples by isotope dilution nano-ultraperformance liquid chromatography–quadrupole time-of-flight mass spectrometry (Q-TOF-MS)
- Identification and quantification of triiodothyronine and thyroxine in rat serum samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Caractéristiques et avantages
- Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
- Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
- Rigorously tested through real-time stability studies to ensure accuracy and shelf life
- Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
- Flame sealed under argon into ampoules for long-term shelf life
- Offered in a convenient, DEA-exempt format to improve laboratory efficiency
Informations légales
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1
Organes cibles
Eyes,Central nervous system
Code de la classe de stockage
3 - Flammable liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
49.5 °F - closed cup
Point d'éclair (°C)
9.7 °C - closed cup
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Certificats d'analyse (COA)
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Les clients ont également consulté
Min Kyong Moon et al.
European journal of endocrinology, 168(6), 805-810 (2013-03-21)
Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. A total of 100 euthyroid men (free triiodothyronine
Vasiliki Michopoulos et al.
Fertility and sterility, 99(7), 2084-2091 (2013-03-20)
To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA.
Susana B Bravo et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2431-2441 (2013-03-30)
Mechanisms of thyroid physiology and cancer are principally studied in follicular cell lines. However, human thyroid cancer lines were found to be heavily contaminated by other sources, and only one supposedly normal-thyroid cell line, immortalized with SV40 antigen, is available.
Min Wang et al.
Neuro endocrinology letters, 34(1), 62-70 (2013-03-26)
To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect. The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells
Laura Fozzatti et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7850-7855 (2013-04-24)
Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicates that the dominant negative activity of mutants underlies the pathological manifestations. However, the molecular mechanisms by which TRα1 mutants exert dominant negative activity in vivo
Articles
Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.
Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.
Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.
Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.
Protocoles
Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.
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