M-021

(±)-Methadone-D3 solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonyme(s) : DL-Methadone-d₃ solution, DL-6-Dimethylamino-4,4-diphenyl-3-heptanone-1,1,1-d₃ solution, DL-Methadone-(heptyl-1,1,1-d₃) solution
• Formule empirique (notation de Hill): C₂₁D₃H₂₄NO
• Numéro CAS: 60263-63-0
• Poids moléculaire : 312.46
• Numéro CE : 200-659-6
• Numéro MDL: MFCD00673285
• Code UNSPSC : 41116107
• ID de substance PubChem : 329817743
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• Concentration: 1.0 mg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Changement de masse: M+3
• Température de stockage: 2-8°C
• Chaîne SMILES: [2H]C([2H])([2H])CC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2
• InChI: 1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/i1D3
• Clé InChI: USSIQXCVUWKGNF-FIBGUPNXSA-N

Description

Description générale

A stable-labeled internal standard applicable for use in isotope dilution methods or quantitation of methadone levels by GC/MS or LC/MS in forensic analysis, urine drug testing, pain prescription monitoring or clinical toxicology applications. Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine^®, Amidone, Methadose^®, Physeptone, or Heptadon.

Application

• Opioid pharmacokinetics research: (±)-Methadone-D3 solution is utilized in opioid pharmacokinetics research to track and analyze the metabolism of methadone, providing insights into its pharmacological properties and interaction dynamics (Beck et al., 2010).


• MethaDonemetabolism study: As a deuterated methaDonesolution, it is critical for detailed studies on drug metabolism, aiding in the understanding of methadone′s biotransformation and its implications for therapeutic efficacy and safety (Anggård et al., 1979).


• Mass spectrometry internal standard: Methadone-D3 serves as an internal standard in mass spectrometry, enhancing the precision of quantitative analyses in forensic and clinical toxicology (Johansen and Jensen, 2004).


• Analytical research: Employed in analytical research, Methadone-D3 solution facilitates the development of advanced analytical methods for the detection and quantification of opioids in various biological matrices (Lucas et al., 2000).


• Drug metabolism research: This solution is key in drug metabolism research, helping to identify the metabolic pathways and excretion profiles of methadone, which is crucial for developing effective dosing regimens and understanding drug interactions (Kintz et al., 1998).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Dolophine is a registered trademark of Roxane Laboratories, Inc.

Methadose is a registered trademark of Mallinckrodt Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup