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D-073

Supelco

5α-Dihydrotestosterone (DHT) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonyme(s) :

5α-Dihydrotestosterone solution, 5-alpha-Dihydrotestosterone, DHT, Dihydrotestosterone, 5α−DHT solution

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About This Item

Formule empirique (notation de Hill):
C19H30O2
Numéro CAS:
521-18-6
Poids moléculaire :
290.44
Numéro MDL:
MFCD00003667
Code UNSPSC :
41116107
ID de substance PubChem :
329798632
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing
clinical testing

Format

single component solution

Température de stockage

−70°C

Chaîne SMILES 

C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1

Clé InChI

NVKAWKQGWWIWPM-ABEVXSGRSA-N

Description générale

This Certified Spiking Solution® is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports testing.

5α-Dihydrotestosterone (DHT) is a steroid hormone and metabolite of the natural androgen, testosterone, formed by the action of NADPH-dependent enzyme 5α-reductase. It has been implicated in a broad range of diseases from male pattern baldness to benign prostatic hyperplasia and prostate cancer. As an anabolic steroid, DHT has also been used as a performance-enhancing drug to promote muscle growth.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Simultaneous analysis of testosterone and 5α-dihydrotestosterone using a benchtop gas chromatograph-mass spectrophotometer (GC-MS) in human serum samples
  • Liquid chromatography-electrospray ionization-tandem mass spectrometric (LC/ESI-MS/MS) determination of testosterone and 5α-dihydrotestosterone following their proton affinitive derivatization using picolinic acid and its analogs
  • Determination of testosterone and 5α-dihydrotestosterone in plasma and testis samples of fathead minnow by a gas chromatography-tandem mass spectrometric (GC-MS/MS) method
  • Multi-residue screening of epitestosterone, testosterone, 5α-dihydrotestosterone, dehydroepiandrosterone, androsterone, and etiocholanolone in urine samples by high-resolution full scan-electrospray ionization-liquid chromatography (HR-FS-ESI-LC) combined with quadrupole orbitrap mass spectrometer (Q/Orbitrap MS) following requirements of World Antidoping Agency (WADA)
  • Quantitative analysis of nine hydroxy-androgens and their conjugates by a stable isotope dilution liquid chromatography-electrospray ionization-tandem mass spectrometry (SID-LC-ESI-MS/MS) based method following their derivatization using picolinic acid

Caractéristiques et avantages

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

A-075

Androstenedione solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

A-084

Androstene-3,17-dione-2,3,4-13C3 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

D-077

5α-Dihydrotestosterone-D3 (16,16,17-D3) solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

E-058

Epitestosterone solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

H-059

6β-Hydroxytestosterone solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-906

17α-Methyltestosterone solution, 1.0 mg/mL in 1,2-dimethoxyethane, ampule of 1 mL, certified reference material, Cerilliant®

N-050

Nandrolone solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

T-034

6β-Hydroxytestosterone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

T-037

Testosterone solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

T-046

Testosterone-d3 (16, 16, 17-d3) solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

T-070

Testosterone-2,3,4-13C3 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

T-510

Testosterone CRM in Serum solution, 2000 ng/dL (Stripped Serum), certified reference material, ampule of 1 mL, Cerilliant®

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes,Central nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sigma-Aldrich

96992

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Testosterone solution 1.0 mg/mL in 1,2-dimethoxyethane, drug standard

Supelco

T5411

Testosterone solution

Paula M Marchetti et al.
Annals of clinical biochemistry, 50(Pt 2), 95-107 (2013-02-23)
Dihydrotestosterone (DHT) is the most potent natural androgen in humans. There has been an increasing interest in this androgen and its role in the development of primary and secondary sexual characteristics as well as its potential roles in diseases ranging
Francesca Argellati et al.
Anticancer research, 33(3), 815-820 (2013-03-14)
To investigate periostin (POSTN) expression in the LNCaP cell line. Our LNCaP strain did not constitutively express the POSTN gene. Through cell transfection with a cloning vector, we developed an LNCaP cell line that stably expressed POSTN. LNCaP wild-type and
Jee In Kim et al.
American journal of physiology. Renal physiology, 305(1), F61-F70 (2013-05-10)
Male gender and the male hormone testosterone increase susceptibility to kidney ischemia and reperfusion (I/R) injury, which is associated with inflammatory responses. Possible involvement of histone deacetylase (HDAC) in inflammatory responses has been suggested. We investigated the gender-specific role of
Michael T Sellix et al.
Endocrinology, 154(4), 1636-1647 (2013-02-19)
Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in
Julia Johansson et al.
PloS one, 8(1), e54357-e54357 (2013-01-26)
In rats with dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS), repeated low-frequency electrical stimulation of acupuncture needles restores whole-body insulin sensitivity measured by euglycemic hyperinsulinemic clamp. We hypothesized that electrical stimulation causing muscle contractions and manual stimulation causing needle sensation have
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