A-150

Aprobarbital solution

1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant^®

• Formule empirique (notation de Hill): C₁₀H₁₄N₂O₃
• Numéro CAS: 77-02-1
• Poids moléculaire : 210.23
• Numéro MDL: MFCD00057559
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1 mg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: O=C1C(C(C)C)(CC=C)C(NC(N1)=O)=O
• InChI: 1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15)
• Clé InChI: UORJNBVJVRLXMQ-UHFFFAOYSA-N

Description

Description générale

Aprobarbital, also known as aprobarbitone, is sold as Oramon, Somnifaine and Allonal. Aprobarbital has sedative, hypnotic and anticonvulsant properties and was primarily used for the treatment of insomnia. This Snap-N-Spike Reference Solution is applicable for use in applications including clinical toxicology, medication monitoring, urine drug testing, and forensic analysis by LC-MS/MS or GC/MS.

Application

• Rapid quantification of phenobarbital and barbital in human whole blood by liquid-liquid extraction combined with DART-orbitrap-HRMS: This method showcases the use of Aprobarbital-related compounds for forensic toxicology, highlighting its potential in precise legal and clinical diagnostics (Ke et al., 2023).


• Quantitative Determination of Methohexital in Human Whole Blood by Liquid Chromatography Tandem Mass Spectrometry: The study emphasizes the critical role of barbiturates like Aprobarbital in therapeutic monitoring, contributing to safer and more effective drug administration protocols (Zhang et al., 2021).


• Occurrence and fate of barbiturates in the aquatic environment: Research into environmental toxicology of compounds including Aprobarbital, providing insights into pollution control and drug lifecycle analysis (Peschka et al., 2006).


• Determinations of zidovudine/didanosine/nevirapine and zidovudine/didanosine/ritonavir in human serum by micellar electrokinetic chromatography: This analytical technique underlines the broader utility of methodologies applicable to barbiturate analysis like Aprobarbital in complex biological matrices (Fan and Stewart, 2002).


• Determination of lamivudine/stavudine/efavirenz in human serum using liquid chromatography/electrospray tandem mass spectrometry with ionization polarity switch: Demonstrates advanced analytical capabilities potentially extendable to Aprobarbital, enhancing drug monitoring and pharmacokinetic studies (Fan et al., 2002).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup