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Key Documents

870604P

Avanti

oxPAPC

Avanti Research™ - A Croda Brand 870604P, powder

Synonyme(s) :

oxPAPC, Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine

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About This Item

Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 500 μg (870604P-500ug)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 870604P

Type de lipide

phosphoglycerides
phospholipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Description générale

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is a mixture of oxidized phospholipid and a bioactive constituent of oxidized low-density lipoproteins (LDLs).

Application

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is suitable for use to stimulate murine alveolar macrophages in vitro. It is also suitable for use to study its effects on human aortic endothelial cell metabolic reprogramming.

Actions biochimiques/physiologiques

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) show barrier-protective effects on human pulmonary endothelial monolayers. This lipid induce endothelial dysfunction by stimulating both pro- and anti-inflammatory pathways. OxPAPC is highly accumulated in atherosclerotic lesions and other sites of chronic inflammation.

Conditionnement

5 mL Clear Glass Sealed Ampule (870604P-500ug)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
Birukov KG, et al.
Microvascular Research, 67(1), 18-28 (2004)
Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC
Li R, et al.
Circulation Research, 98(5), 642-650 (2006)
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury
Dubey PK, et al.
International Immunology, 29(2), 79-85 (2017)
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Hitzel J, et al.
Nature Communications, 9(1), 2292-2292 (2018)
Corinne M Spickett et al.
Free radical biology & medicine, 51(12), 2133-2149 (2011-10-11)
Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products

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