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840512C

Avanti

16:0 Phosphatidylethanol

1,2-dipalmitoyl-sn-glycero-3-phosphoethanol (sodium salt), chloroform

Synonyme(s) :

1,2-dihexadecanoyl-sn-glycero-3-phosphoethanol (sodium salt)

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About This Item

Formule empirique (notation de Hill):
C37H72O8PNa
Numéro CAS:
92609-90-0
Poids moléculaire :
698.93
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

liquid

Conditionnement

pkg of 1 × 2.5 mL (840512C-25mg)
pkg of 1 × 20 mL (840512C-500mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 840512C

Concentration

10 mg/mL (840512C-25mg)
25 mg/mL (840512C-500mg)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C37H73O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-36(38)42-33-35(34-44-46(40,41)43-6-3)45-37(39)32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h35H,4-34H2,1-3H3,(H,40,41);/q;+1/p-1/t35-;/m1./s1

Clé InChI

MAGNEPCJIVJZIK-RUQJKXHKSA-M

Description générale

Phosphatidylethanol (PEth) is an abnormal phospholipid found in the cellular membrane. It is spotted in the liver, skeletal muscle, brain and kidney of rat when its mainly exposed to ethanol. 16:0 Phosphatidylethanol/(1,2-dipalmitoyl-sn-glycero-3-phosphoethanol) has two palmitic acid chains.

Application

16:0 Phosphatidylethanol (Peth)/(1,2-dipalmitoyl-sn-glycero-3-phosphoethanol) may be used:
  • as an internal standard in liquid chromatography−mass spectrometry (LC-MS) analysis of PEth in human whole blood
  • as an internal standard to spike blood samples for in liquid chromatography high-resolution mass spectrometry (LC−HRMS) analysis
  • as a standard in calibration curve generation and validation of ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS)

Actions biochimiques/physiologiques

Phosphatidylethanol can be used as a biomarker in blood for chronic alcohol use.

Conditionnement

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (840512C-500mg)
5 mL Clear Glass Sealed Ampule (840512C-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Organes cibles

Liver,Kidney, Respiratory system

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

does not flash

Point d'éclair (°C)

does not flash

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Guido Viel et al.
International journal of molecular sciences, 13(11), 14788-14812 (2012-12-04)
The present paper aims at a systematic review of the current knowledge on phosphatidylethanol (PEth) in blood as a direct marker of chronic alcohol use and abuse. In March 2012, the search through "MeSH" and "free-text" protocols in the databases
Alessandro Nalesso et al.
Journal of chromatography. A, 1218(46), 8423-8431 (2011-10-18)
Phosphatidylethanol (PEth) is a group of aberrant phospholipids formed in cell membranes in the presence of ethanol by the catalytic action of the enzyme phospholipase D on phosphatidylcholine. Recently published literature has demonstrated the existence of several molecular species of
Siming Wang et al.
Talanta, 166, 315-320 (2017-02-19)
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted
Natalie Kummer et al.
Analytical and bioanalytical chemistry, 408(3), 825-838 (2015-11-26)
Phosphatidylethanol species (PEths) are promising biomarkers of alcohol consumption. Here, we report on the set-up, validation, and application of a novel UHPLC-ESI-MS/MS method for the quantification of PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 in whole blood (30 μL) and

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